Sprache
englisch

Titel englisch
No association of clock gene T3111C polymorphism and affective disorders

Autor*in
Bailer U, Wiesegger G, Leisch F, Fuchs K, Leitner

veröffentlicht in
Fachzeitschrift

Titel der Fachzeitschrift
European Neuropsychopharmacology

Jahr
2005

Ausgabe/Heft
15

Seite von
51

Seite bis
55

Abstract englisch
CLOCK was hypothesised to be related to susceptibility of affective disorders. To test subsamples of affectively disordered patients, we examined age of onset (AoO), numbers of episodes and melancholic type of clinical manifestation. Using PCR and RFLP, we investigated in patients with unipolar depression and bipolar disorder (BP) whether the CLOCK T3111C SNP is associated with affective disorders (n=102) compared to healthy controls (n=103). No differences were found either in genotype or allele frequency distributions of T3111C polymorphism between patients compared to healthy controls (p0.2). No deviations from Hardy-Weinberg Equilibrium (HWE) were detected either in patients, or healthy controls. Results suggest that there is no association between the T3111C SNP and affective disorders in general. Data of our sample replicate prior findings of Desan et al. [Am. J. Med. Genet. 12 (2000) 418]. Subsamples of patients with high numbers of affective episodes did show some deviations in genotypes (p=0.0585).